투고논문


JKMRS Volume 23, No 1, pp 12, Measuring T1 contrast in ex-vivo...
2019년 03월 20일 / 조회수: 595

Measuring T1 contrast in ex-vivo prostate tissue at the Earth’s magnetic field


Sangwon Oh1,*, Jae Ho Han2, Ji Eun Kwon2, Jeong Hyun Shim1, Seong-Joo Lee1, Seong-Min Hwang1, Ingo Hilschenz1, and Kiwoong Kim1


1 Ultra-low Magnetic Field Team, Korea Research Institute of Standards and Science, Daejeon 34113, Republic of Korea

2 Department of Pathology, Ajou University School of Medicine, Suwon 16499, Republic of Korea


Received Mar 8, 2019; Accepted Mar 17, 2019


Abstract

A former study has shown that the spin-lattice relaxation time (T1) in cancerous prostate tissue had enhanced contrast at an ultra-low magnetic field, 132 uT. To study the field dependence and the origin of the contrast we measured T1 in pairs of ex-vivo prostate tissues at the Earth’s magnetic field. A portable and coil-based nuclear magnetic resonance (NMR) system was adopted for T1 measurements at 40 uT. The T1 contrast, delta = 1 - T1 (more cancer)/T1(less cancer), was calculated from each pair. Additionally, we performed pathological examinations such as Gleason’s score, cell proliferation index, and micro-vessel density (MVD), to quantify correlations between the pathological parameters and T1 of the cancerous prostate tissues.


*Address correspondence to: Sangwon Oh, Ultra-low Magnetic Field Team, Korea Research Institute of Standards and Science, Daejeon 34113, Republic of Korea, Tel: 82-42-604-1117, E-mail: sangwon.oh@kriss.re.kr

첨부파일 3_Oh et al.pdf