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JKMRS Volume 21, No 4, pp 139; Synthesis of α-oximinoketones, ...
2017년 12월 21일 / 조회수: 200

Synthesis of α-oximinoketones, Precursor of CO2 Reduction Macrocyclic Coenzyme F430 Model Complexes

 

 

Gilhoon Kim and Hoshik Won*

 

 

Department of Chemical and Molecular Engineering, Hanyang University, Ansan, 15588, Republic of Korea


Abstract Ni(II) containing coenzyme F430 catalyzes the reduction of CO2 in methanogen. Macrocyclic Ni(II) complexes with N,O shiff bases have been received a great attention since metal ions play an important role in the catalysis of reduction. The reducing power of metal complexes are supposed to be dependent on oxidoreduction state of metal ion and structural properties of macrocyclic ring moiety that can enhance electrochemical properties in catalytic process. Six different α-oximinoketone compounds, precursor of macrocyclic ligands used in CO2 reduction coenzyme F430 model complexes, were synthesized with yields over 90% and characterized by NMR. The molecular geometries of a-oximinoketone analogues were fully optimized at Beck’s-three-parameter hybrid (B3LYP) method in density functional theory (DFT) method with 6-31+G* basis set using the ab initio program. In order to understand molecular planarity and substitutional effects that may enhance reducing power of metal ion are studied by computing the structure-dependent 13C-NMR chemical shift and comparing with experimental results.

 

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