|JKMRS Volume 21, No 2, pp 55; NMR Tools to Decipher Dynamic St...|
|2017년 06월 20일 / 조회수: 223|
NMR Tools to Decipher Dynamic Structure of RNA
Janghyun Lee and Byong-Seok Choi*
Department of Chemistry, KAIST, Daejeon 34141, South Korea
Abstract It is now well established that RNAs exhibit fundamental roles in regulating cellular processes. Many of these RNAs do not exist in a single conformation. Rather, they undergo dynamic transitions among many different conformations to mediate critical interactions with other biomolecules such as proteins, RNAs, DNAs, or small molecules. Here, we briefly review NMR techniques that describe the dynamic behavior of RNA by determining structural, kinetic, and thermodynamic properties.