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JKMRS Volume 21, No 1, pp 26; Elucidating the Dynamic Properti...
2017년 03월 20일 / 조회수: 265

Elucidating the Dynamic Properties of Globular Protein using Predicted Order Parameters and 15N NMR Relaxation

 

 

Jong-Jae Yi1,ǂ, Won-Je Kim2,ǂ, Jin-Kyu Rhee3, Jongsoo Lim4, Bong-Jin Lee2 and Woo Sung Son1,*

 

 

1College of pharmacy, CHA University, 120 Haeyong-ro, Pocheon-si, Gyeonggi-do, 11160, Republic of Korea

2College of pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea

3Department of Food Science and Engineering, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea

4Discovery Technology Team, Dong-A ST Research Institute, 21 Geumhwa-ro 105beon-gil, Yongin-si, Gyeonggi-do, 17073, Republic of Korea


Abstract Dynamic properties of proteins can present key information on protein-ligand and protein-protein interaction. Despite their usefulness, the properties of protein dynamics have not been obtained easily due to protein stability and short-term measurement. Here, it is shown that combined method for analysis of dynamical properties. It utilizes predicted order parameter and NMR relaxation data such as T1, T2, and heteronuclear NOE. The suggested method could be used to know the flexibility of protein roughly without precise dynamical parameters such as order parameters through model-free analysis.

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