JKMRS Volume 21, No 1, pp 26; Elucidating the Dynamic Properti... | |
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2017년 03월 20일 / 조회수: 593 | |
Elucidating the Dynamic Properties of Globular Protein using Predicted Order Parameters and 15N NMR Relaxation
Jong-Jae Yi1,ǂ, Won-Je Kim2,ǂ, Jin-Kyu Rhee3, Jongsoo Lim4, Bong-Jin Lee2 and Woo Sung Son1,*
1College of pharmacy, CHA University, 120 Haeyong-ro, Pocheon-si, Gyeonggi-do, 11160, Republic of Korea 2College of pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea 3Department of Food Science and Engineering, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea 4Discovery Technology Team, Dong-A ST Research Institute, 21 Geumhwa-ro 105beon-gil, Yongin-si, Gyeonggi-do, 17073, Republic of Korea Abstract
Dynamic
properties of proteins can present key information on protein-ligand and
protein-protein interaction. Despite their usefulness, the properties of
protein dynamics have not been obtained easily due to protein stability and
short-term measurement. Here, it is shown
that combined method for analysis of dynamical properties. It utilizes
predicted order parameter and NMR relaxation data such as T1, T2,
and heteronuclear NOE. The suggested
method could be used to know the flexibility of protein roughly without precise dynamical parameters such as order
parameters through model-free analysis. |
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첨부파일 | 5_201703_손우성.pdf |