|JKMRS Volume 20, No 1, pp 13; The difference of metabolic prof...|
|2016년 03월 19일 / 조회수: 173|
The difference of metabolic profile between male and female zebrafish
Dahye Yoon, Jin Choi, Hyeonsoo Choi and Suhkmann Kim*
Department of Chemistry, Center for Proteome Biophysics and Chemistry Institute for Functional Materials, Pusan National University, 2, Busandaehak-ro 63beong-gil, Geumjeong-gu, Busan, 46241, Republic of Korea
Received Jan 12, 2016; Revised Feb 15, 2016; Accepted Feb 19, 2016
Various experiments using zebrafish have been highlighted recently in the scientific community. Because it is possible to conduct practical experiment from various neurological research to area of genetic study or toxicity experiment. However, gender difference effects are nearly not considered. If the gender differences of zebrafish are considered it is possible to obtain more accurate data. In this study, zebrafish which have different genders were compared each other with NMR-based metabolomics. The extracts of male and female zebrafish were measured by 600 MHz NMR spectrometer. Statistical analysis and target profiling were conducted. As a result, muscle related metabolites were observed in male zebrafish and nerve related metabolites were observed in female zebrafish.