JKMRS Volume 18, No 2, pp 82-88;Four sesquiterpenes isolated f... | |
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2014년 12월 17일 / 조회수: 715 | |
Abstract Three bicyclic and one
monocyclic sesquiterpenoids were isolated from the marine sponge Topsentia species. Their planar
structures were completely determined from a combination of extensive 1D and 2D
NMR experiments, and also the relative stereochemistry on the chiral centers
were established by the ROESY experiment.
Compound 1 was determined as a new stereoisomer. Furthermore, the NMR
spectral data for compounds 2 and 4, of which have not been reported, were listed.
Four compounds did not show any cytotoxicity, instead compound 4 exhibited
moderate antifungal activity against Candida
albicans. Keywords NMR, sesquiterpenoid, sponge Topsentia sp., antifungal activity |
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