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JKMRS Volume 18, No 2, pp 82-88;Four sesquiterpenes isolated f...
2014년 12월 17일 / 조회수: 715

Abstract   Three bicyclic and one monocyclic sesquiterpenoids were isolated from the marine sponge Topsentia species. Their planar structures were completely determined from a combination of extensive 1D and 2D NMR experiments, and also the relative stereochemistry on the chiral centers were established by the ROESY experiment.  Compound 1 was determined as a new stereoisomer. Furthermore, the NMR spectral data for compounds 2 and 4, of which have not been reported, were listed. Four compounds did not show any cytotoxicity, instead compound 4 exhibited moderate antifungal activity against Candida albicans.

 

Keywords   NMR, sesquiterpenoid, sponge Topsentia sp., antifungal activity

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