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JKMRS Volume 18, No 1, pp 10-14; Metabolic perturbation of an ...
2014년 06월 20일 / 조회수: 1003

Metabolic perturbation of an Hsp90 C-domain inhibitor in a lung cancer cell line, A549 studied by NMR-based chemometric analysis

Su-Jung Hur, Hye-Won Lee, Ai-Hyang Shin, and Sung Jean Park·························································10


Abstract   Hsp90 is a good drug target molecule that is involved in regulating various signaling pathway in normal cell and the role of Hsp90 is highly emphasized especially in cancer cells. Thus, much efforts for discovery and development of Hsp90 inhibitor have been continued and a few Hsp90 inhibitors targeting the N-terminal ATP binding site are being tested in the clinical trials. There are no metabolic signature molecules that can be used to evaluate the effect of Hsp90 inhibition. We previously found a potential C-domain binder named PPC1 that is a synthetic small molecule. Here we report the metabolomics study to find signature metabolites upon treatment of PPC1 compound in lung cancer cell line, A549 and discuss the potentiality of metabolomic approach for evaluation of hit compounds.


Keywords   Hsp90, C-domain inhibitor, biomarker,

metabolomics


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