투고논문
| JKMRS Volume 17, No 1 54-58; Backbone 1H, 15N, and 13C Resonan... | |
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| 2013년 06월 20일 / 조회수: 848 | |
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Backbone 1H, 15N, and 13C Resonances Assignment and Secondary Structure Prediction of SAV0506 from Staphylococcus aureus In Gyun Lee, Ki-Young Lee, Ji-hun Kim , Susanna Chae and Bong-Jin Lee* 1Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, San 56-1, Shillim-Dong, Kwanak-Gu, Seoul 151-742, Korea Received June 1, 2013; Revised June 7, 2013; Accepted June 10, 2013 Abstract SAV0506 is an 87 residue hypothetical protein from Staphylococcus aureus strain Mu50 and also predicted to have similar function to ribosome associated heat shock protein, Hsp 15. Hsp15 is thought to be involved in the repair mechanism of erroneously produced 50S ribosome subunit. In this report, we present the sequence specific backbone resonance assignment of SAV0506. About 82.5% of all resonances could be assigned unambiguously. By analyzing deviations of the Cα and Cβ chemical shift values, we could predict the secondary structure of SAV0506. This study is an essential step towards the structural characterization of SAV0506. Keywords Staphylococcus aureus, SAV0506, Hsp15, NMR |
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| 첨부파일 | 8이봉진.pdf |