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JKMRS Volume 17, No 1 47-53; Four new cyclic peroxides from th...
2013년 06월 20일 / 조회수: 466

Four new cyclic peroxides from the Marine Sponge Plakortis simplex

 

 

Buyng Su Hwang and Jung-Rae Rho *

 

 

Department of Oceanography, Kunsan National University, Jeonbuk 573-701, Korea

 

 

Received June 4, 2013; Revised June 07, 2013; Accepted June 10, 2013

 


Abstract   Four new cyclic peroxide compounds (1 ~ 4) were isolated from the marine sponge Plakortis simplex. Their structures including relative stereochemistry were determined by MS and NMR analysis. All compounds, a side carbon chain with 10 carbons, were very unstable. After transformation into methyl ester analogues, the structure determination was conducted. Compounds 1a and 2a are stereoisomers, assigned as 3S*, 4S*, 6R* and 3R*, 4S*, 6R*, respectively. Similarly, compounds 3a and 4a, replaced the methoxy group with an aliphatic methyl, are also stereoisomers. Compounds 1a and 2a exhibited the strong antifungal effect against the fungus Candida albicans.

 

Keywords   1D and 2D NMR, Plakortis simplex, stereoisomer, cyclic peroxide, antifungal activity

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