|JKMRS Volume 17, No 1 1-10; Applications of NMR spectroscopy b...|
|2013년 06월 20일 / 조회수: 500|
Applications of NMR spectroscopy based metabolomics: a review
Dahye Yoon, Minji Lee, Siwon Kim and Suhkmann Kim*
Department of Chemistry,
Received May 31, 2013; Revised June 06, 2013; Accepted June 10, 2013
Abstract Metabolomics is the study which detects the changes of metabolites level. Metabolomics is a terminal view of the biological system. The end products of the metabolism, metabolites, reflect the responses to external environment. Therefore metabolomics gives the additional information about understanding the metabolic pathways. These metabolites can be used as biomarkers that indicate the disease or external stresses such as exposure to toxicant. Many kinds of biological samples are used in metabolomics, for example, cell, tissue, and bio fluids. NMR spectroscopy is one of the tools of metabolomics. NMR data are analyzed by multivariate statistical analysis and target profiling technique. Recently, NMR-based metabolomics is a growing field in various studies such as disease diagnosis, forensic science, and toxicity assessment.
Keywords NMR, metabolomics, multivariate statistical analysis, target profiling