투고논문

Three new okadaic acid derivatives isolated from

a benthic dinoflagellate Prorocetrum lima

Semin Moon¹, Dong Han Choi², Yeonjung Lee², and Jung-Rae Rho¹*

¹Department of Oceanography, Kunsan National University, Gunsan 54150, Republic of Korea

²Ocean Climate Response and Ecosystem Research Department, Korea Institute of Ocean Science and Technology, Busan 49111, Republic of Korea

Received Sep 12, 2024; Revised Sep 19, 2024; Accepted Sep 19, 2024

Abstract Toxins produced by marine toxigenic algae have garnered growing attention due to their detrimental impacts on marine ecosystem, aquaculture, and human health. Among these, diarrhetic shellfish poisoning (DSP) toxins, such as okadaic acid (OA), are of particular concern. In this study, we report the successful isolation and structural elucidation of three new derivatives of OA from the marine dinoflagellate Prorocentrum lima. These newly identified compounds, OA-2Me-C7, OA-2-Me-C8, and OA-1-Me-C8, were characterized through a comprehensive series of NMR experiments, combined with structural comparisons to the well-known OA. The identification of these derivatives contributes to the expanding knowledge of DSP toxin diversity and provides new insights into the structural variations of these harmful algal toxins.

Keywords 1D and 2D NMR, Prorocentrum lima, Okadaic acid, Okadaic acid diol esters, DSP isolation

* Address correspondence to: Jung-Rae Rho, Department of Oceanography, Kunsan National University, Gunsan 54150, Republic of Korea, Tel: 82-63-469-4606; Fax: 82-63-469-7441; E-mail: jrrho@kunsan.ac.kr