투고논문

Abstract From a marine sponge Dysidea species, four new furanosesquiterterpenoids were isolated and characterized. Their structural elucidation was achieved through an extensive analysis employing NMR, MS data, and DFT method. Notably, all compounds shared as identical molecular formula. Compound 2 was identified as a derivative of compound 1, while compounds 3 and 4 exhibited an identical planar structure. Determination of the configurations of chiral centers in compounds 1 and 2 involved a comparative analysis between measured and calculated ECD spectra, along with the application of DP4+ probability analysis. Distinctly, the configurations of isomers 3 and 4 were established by scrutinizing proton chemical shifts based on the NOE correlation.

Keywords 1D and 2D NMR, Dysidea sp, DFT method, DP4+ probability, configuration determination

* Address correspondence to: Jung-Rae Rho, Department of Oceanography, Kunsan National University, Gunsan 54150, Republic of Korea, Tel: 82-63-469-4606; Fax: 82-63-469-7441; E-mail: jrrho@kunsan.ac.kr