|JKMRS Volume 24, No 4, pp 129, Minireview on Recent Antibody-R...|
|2020년 12월 20일 / 조회수: 193|
Minireview on Recent Antibody-Related NMR Studies
Jinhwa Jang, Ji-Hun Kim*
College of Pharmacy, Chungbuk National University Cheongju, Chungbuk 28160, Republic of Korea
Received Dec 10, 2020; Revised Dec 17, 2020; Accepted Dec 17, 2020
Abstract In a relatively short period, monoclonal antibodies have made dramatic success as therapeutics for various diseases such as cancers and autoimmune diseases and become an important development items for many pharmaceutical companies. In order to develop antibody drug, it is important to investigate the structural characteristics of both antibody and antigen. NMR studies on antibody are extremely challenging due to big huddles such as a big size of protein and isotope labeling, nevertheless, several studies have been reported in 10 years. Here, we analyzed 95 papers dealing with antibody-related NMR studies reported in recent 10 years. We categorized papers into 3 types: 1) structural characterization of antibody, 2) structural characterization of antigen using antibody, 3) amyloidosis caused by fragment of antibody. This work would shed new light on antibody-related NMR studies.
Keywords Nuclear magnetic resonance, antibody, higher order structure, saturation transfer difference, epitope